WHAT IS INTESTINAL PERMEABILITY?
The intestine plays a fundamental role in maintaining our health since it is one of the main ways of contact between our internal environment and the environment through everything we eat. For the proper functioning of the intestine, the functions developed by the intestinal mucosa and by the flora or microbiota are extremely important.
One of the tasks performed by the wall of the small intestine is to absorb or assimilate micronutrients such as vitamins, trace elements, amino acids, fatty acids, ... essential to achieve optimal health.
The role of the small intestine will be optimized, or not, depending on the state of the cells that make up its wall. The intestinal wall behaves like a filter, allowing microelements to pass through and preventing the passage of macromolecules.
An increase in intestinal permeability is due to alterations in the villi and microvilli that are part of the intestinal epithelium composed of a single cell layer and, above all, to alterations in the intercellular spaces of this intestinal epithelium. This alteration causes:
-Massive entry of bacterial or food antigens, entry of pathogens, massive entry of toxins and semi-digested food molecules (peptides, lipids, polysaccharides, ...)
-The repeated introduction of food antigens through the intestinal mucosa could be responsible for immune responses mediated by IgG or IgE antibodies, resulting in a chronic inflammatory reaction.
WHAT DOES THE INTESTINAL PERMEABILITY NETWORK CONSIST OF?
In order to determine the existence of altered intestinal permeability, we have a non-invasive test. This is an analysis that consists of making the patient absorb a solution that contains 2 sugar-alcohols, which are not degraded or metabolized by the body and are of different sizes:
- Lactulose: a large molecule (9,5 A), which represents the macronutrients that, under normal circumstances, do not cross the intestinal barrier.
- Mannitol: a small molecule (6,7 A) that represents the micronutrients that, under normal circumstances, are absorbed by the microvilli of the enterocytes.
The urine of the patient is collected in its entirety during the 5 hours after taking this preparation, meanwhile the patient remains fasting and is only allowed to drink water in the last 2 hours of the test.
Once the molecules in the urine sample have been quantified, it is considered that:
- If lactulose, a large molecule, is obtained in a greater quantity than expected, it is considered that the intestinal mucosa has allowed the passage of this excess molecule as a consequence of an increase in its permeability.
- If mannitol, a small molecule, is obtained in a lower quantity than expected, it is considered that it has been poorly absorbed through the intestinal mucosa as a consequence of a decrease in intestinal permeability, which may be related to problems of malnutrition
- If levels of the two molecules considered normal are obtained, it is understood that the intestinal mucosa has normal permeability.
- Various inflammatory diseases.
- Autoimmune diseases.
- Joint and / or muscle pain.
- Abdominal swelling
- Crohn's disease.
- Urinate on an empty stomach (minimum 6 hours of fasting) and do not save urine.
- Keep fasting until the end of the test.
HOW IS THE TEST DONE?
- The patient should drink the recommended amount from a bottle provided by laboratory personnel that contains the sugars necessary to perform the test.
- Then he will collect all the urine during the 5 hours following the ingestion of the solution, using a graduated container for the subsequent measurement of the total volume.
- You can take absolutely nothing for the first three hours. during the last two hours you can only consume water.
The duration of the test will be 5 hours.
Results will be delivered within 3 weeks.
I NEED A BOWEL PERMEABILITY NET WHAT SHOULD I DO?
- Comply with the conditions prior to conducting the Test.
- We will contact you to give you an appointment.